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KMID : 0370219950390060577
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Yakhak Hoeji
1995 Volume.39 No. 6 p.577 ~ p.584
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Pharmacokinetics and Gastric Adhesion of Aceglutamide Aluminium on The Combination of Antacid in Rats
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조재열/Cho JY
남권호/유은숙/유영효/박명환/박정일/Nam KH/Yoo ES/Yu YH/Park MH/Park JH
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Abstract
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On the combination of antacid, the pharmacokinetics and gastric adhesion of [14C]aceglutamide aluminium complex([14C]AGA) were examined in rats. Specially, this study was focused on the drug interaction that the co-administration of anatacid may affect the oral co-administration of [14C] AGA and antacid(aluminium hydroxide and magnesium hydroxide(AM)), the radioactivity of plasma and urinary recovery was lower than that of [14C]AGA alone administered group. However, the cumulative recovery of radioactivity in feces was increased significantly. The comparative bioavailability of [14C]AGA from the plasma concentration-time curve and urinary recovery was about 60%. In vitro, the effect of antacid on the gastric adhesion of AGA was not significantly different between AGA and AGA/antacid treatment. And it accorded well with the result of in vivo experiment. In conclusion, on the combination of antacid , the oral absorption of AGA was decreased but the gastric adhesion was not affected in respect of drug interaction.
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KEYWORD
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